About Oscillo

Our team combines deep expertise in music neuroscience with the latest advancements in the neuroscience of memory and cognition to develop clinical interventions for severe neurodegenerative conditions. Our co-founders, Dr. Edward Large and Dr. Ji Chul Kim, professors at the University of Connecticut, have dedicated decades to groundbreaking research on the neuroscience of music and the physics of the brain. In 2017, they established Oscillo Biosciences to apply their understanding of neural entrainment to advanced technologies that leverage their knowledge of how music synchronizes neural oscillations (the rhythms of the brain).

In collaboration with Dr. Psyche Loui and her team at Northeastern University, Large and Kim set out to explore the therapeutic potential of music, and enhance its potential as a treatment modality. Their objective was to combine the power of music to activate multiple neural pathways associated with emotion, memory, and cognition, with music’s unique ability to synchronize neural oscillations. The successful implementation of this approach would hold significant promise for the treatment of neurological disorders, particularly Alzheimer’s disease.

Through their research, the team discovered that when rhythmic light pulses at specific frequencies are synchronously combined with musical stimuli, it generates intense and sustained effects. This groundbreaking finding motivated the pursuit of Oscillo’s first clinical application. The team is currently conducting an NIH-funded clinical trial (NCT05984524) involving patients with mild cognitive impairment and early-stage Alzheimer’s disease.